Deltasone (Prednisone)

DELTASONE Tablets contain prednisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Prednisone is a white to practically white, odorless, crystalline powder. It is very slightly soluble in water; slightly soluble in alcohol, in chloroform, in dioxane, and in methanol. The chemical name for prednisone is pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy- and its molecular weight is 358.43. Deltasone (Prednisone) Tablets are available in 5 strengths: 2.5 mg, 5 mg, 10 mg, 20 mg and 50 mg. Inactive ingredients: 2.5 mg-Calcium Stearate, Corn Starch, Erythrosine Sodium, Lactose, Mineral Oil, Sorbic Acid and Sucrose. 5 mg- Calcium Stearate, Corn Starch, Lactose, Mineral Oil, Sorbic Acid and Sucrose. 10 mg-Calcium Stearate, Corn Starch, Lactose, Sorbic Acid and Sucrose. 20 mg-Calcium Stearate, Corn Starch, FD&C Yellow No. 6, Lactose, Sorbic Acid and Sucrose. 50 mg-Corn Starch, Lactose, Magnesium Stearate, Sorbic Acid, Sucrose, and Talc. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.

Prednisone (Deltasone) is in a class of drugs called steroids. Prednisone is a corticosteroid. It works by decreasing or preventing tissues from responding to inflammation. It also modifies the body's response to certain immune stimulation.

Prednisone (Deltasone) is a synthetic corticosteroid, used for suppressing the immune system and inflammation Prednisone prevents the release of substances in the body that cause inflammation. Prednisone is used to treat many different conditions such as allergic disorders, skin conditions, ulcerative colitis, arthritis, lupus, psoriasis, asthma, multiple sclerosis, or breathing disorders. It may be given to treat primary or secondary adrenal cortex insufficiency (lack of sufficient adrenal hormone in the body).

It is used in treating all of the following: Allergic conditions severe, Abnormal adrenal gland development, Certain cancers (along with other drugs), Blood disorders, Diseases of the connective tissue including systemic lupus erythematosus, Eye diseases of various kinds, Fluid retention due to "nephrotic syndrome" (a condition in which damage to the kidneys causes protein to be lost in the urine), Flare-ups of multiple sclerosis, Lung diseases, including tuberculosis, Meningitis (inflamed membranes around the brain), Prevention of organ rejection, Severe flare-ups of ulcerative colitis or enteritis (inflammation of the intestines), Rheumatoid arthritis and related disorders, Skin diseases, Trichinosis (with complications), Thyroid gland inflammation.

Deltasone (Prednisone) lowers your resistance to infections and can make them harder to treat. Deltasone may also mask some of the signs of an infection, making it difficult for your doctor to diagnose the actual problem. Use Deltasone (Prednisone) as directed by your doctor. Check the label on the medicine for exact dosing instructions. Prednisone may also be used for other purposes not listed in this medication guide as determined by your doctor.

How Taken.

Take Deltasone (Prednisone) by mouth with food. Deltasone (Prednisone) comes as a dose pack with specific instructions as to when to take the medicine or how much to take each time. It is very important to follow these instructions as closely as possible. Do not miss any doses. If you need long-term Deltasone treatment, your doctor may prescribe alternate-day therapy, in which you take the medication only every other morning. The "resting day" gives your adrenal glands a chance to produce some hormone naturally so they will not lose the ability. If you are on alternate-day therapy or have been prescribed a single daily dose, take Deltasone in the morning with breakfast (about 8 AM). If you have been prescribed several doses per day, take them at evenly spaced intervals around the clock. Patients on long-term Deltasone therapy should wear or carry identification. Before taking prednisone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids. You should not use this medication if you are allergic to prednisone, or if you have a fungal infection anywhere in your body. Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment. Prednisone (Deltasone) can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication. Tell your doctor about any illness or infection you have had within the past several weeks. Avoid being near people who are sick or have infections. Do not receive a "live" vaccine while you are taking prednisone. Vaccines may not work as well while you are taking a steroid. Do not stop using prednisone suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping prednisone. Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Prednisone (Deltasone) can weaken your immune system, making it easier for you to get an infection. Steroids can also worsen an infection you already have, or reactivate an infection you recently had. Before taking prednisone, tell your doctor about any illness or infection you have had within the past several weeks.

Other medical conditions you should tell your doctor about before taking prednisone include: liver disease (such as cirrhosis); kidney disease a thyroid disorder diabetes; a history of malaria tuberculosis; osteoporosis a muscle disorder such as myasthenia gravis glaucoma or cataracts; herpes infection of the eyes stomach ulcers, ulcerative colitis, or diverticulitis depression or mental illness congestive heart failure; or high blood pressure Possible food and drug interactions when taking this medication.

Deltasone may decrease your carbohydrate tolerance or activate a latent case of diabetes. If you are already taking insulin or oral medication for diabetes, make sure your doctor knows this; you may need an increased dosage while you are being treated with Deltasone. If you have a blood-clotting disorder caused by a vitamin K deficiency and are taking Deltasone, check with your doctor before you use aspirin. You may be at risk of convulsions if you take the immunosuppressant drug cyclosporine (Sandimmune) while being treated with Deltasone. If Deltasone is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

Check with your doctor before combining Deltasone with any of the following:Amphotericin B (Fungizone) Blood thinners such as Coumadin Carbamazepine (Tegretol) Estrogen drugs such as Premarin Ketoconazole (Nizoral) Oral contraceptives Phenobarbital (Donnatal, others) Phenytoin (Dilantin) Potent diuretics such as Lasix Rifampin (Rifadin) Troleandomycin (Tao) If you have any of these conditions, you may need a dose adjustment or special tests to safely take prednisone.

FDA pregnancy category C. Prednisone may be harmful to an unborn baby. If you are pregnant or plan to become pregnant, inform your doctor immediately. Deltasone should be taken during pregnancy or while breastfeeding only if clearly needed and only if the benefit outweighs the potential risks to the child. Prednisone can pass into breast milk and may harm a nursing baby. Do not use prednisone without telling your doctor if you are breast-feeding a baby. Steroids can affect growth in children. Talk with your doctor if you think your child is not growing at a normal rate while using prednisone. Do not stop using prednisone (Deltasone) suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping prednisone . Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency. Any doctor, dentist, or emergency medical care provider who treats you should know that you are taking steroid medication. General Precautions Drug-induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should, be administered concurrently. There is an enhanced effect of corticosteroids on patients with hypothyroidism and in those with cirrhosis. Corticosteroids should be used cautiously in patients with ocular herpes simplex because of possible cornmeal perforation. The lowest possible dose of corticosteroid should be used to control the condition under treatment, and when reduction in dosage is possible, the reduction should be gradual. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes, and severe depression, to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids. Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess or other pyogenic infection; diverticulitis; fresh intestinal anastomoses; active or latent peptic ulcer; renal insufficiency; hypertension; osteoporosis; and myasthenia gravis. Growth and development of infants and children on prolonged corticosteroid therapy should be carefully observed. Kaposi's sarcoma has been reported to occur in patients receiving corticosteroid therapy. Discontinuation of corticosteroids may result in clinical remission. Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not show that corticosteroids affect the ultimate outcome or natural history of the disease. The studies do show that relatively high doses of corticosteroids are necessary to demonstrate a significant effect. Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment, a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used. Convulsions have been reported with concurrent use of methylprednisolone and cyclosporin. Since concurrent use of these agents results in a mutual inhibition of metabolism, it is possible that adverse events associated with the individual use of either drug may be more apt to occur.

Dosage is determined by the condition being treated and your response to the drug. Typical starting doses can range from 5 milligrams to 60 milligrams a day. Once you respond to the drug, your doctor will lower the dose gradually to the minimum effective amount. For treatment of acute attacks of multiple sclerosis, doses of as much as 200 milligrams per day may be given for a week, followed by 80 mg every other day for a month. Multiple Sclerosis In the treatment of acute exacerbations of multiple sclerosis daily doses of 200 mg of prednisone for a week followed by 80 mg every other day for 1 month have been shown to be effective. (Dosage range is the same for prednisone and prednisone.) If you miss a dose of Deltasone (Prednisone) , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Avoid drinking alcohol while you are taking prednisone.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: problems with your vision swelling, rapid weight gain, feeling short of breath; severe depression, unusual thoughts or behavior, seizure (convulsions); bloody or tarry stools, coughing up blood pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate); low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling); or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure). Less serious side effects may include: sleep problems (insomnia), mood changes acne, dry skin, thinning skin, bruising or discoloration increased sweating slow wound healing headache, dizziness, spinning sensation nausea, stomach pain, bloating; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist). There are many other medicines that can interact with steroids. Below is only a partial list of these medicines: aspirin (taken on a daily basis or at high doses); a diuretic (water pill); a blood thinner such as warfarin (Coumadin); cyclosporine (Gengraf, Neoral, Sandimmune); insulin or diabetes medications you take by mouth antibiotics such as ketoconazole (Nizoral), rifampin (Rifadin, Rifater, Rifamate, Rimactane), or troleandomycin (Tao); or seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton). This list is not complete and there may be other drugs that can interact with prednisone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Store prednisone at room temperature away from moisture and heat. Store at room temperature 20-25 degrees C (68-77 degrees F), and keep away from moisture. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use prednisone only for the indication prescribed. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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